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The AMA also updated CPT 90661 effective January 1, 2025, removing the term "preservative-free" from the code description

Unfunded Mandates Reform Act (UMRA) Section 202 of the Unfunded Mandates Reform Act of 1995 (UMRA) also requires that agencies assess anticipated costs and benefits before issuing any rule whose mandates require spending in any 1 year of $100 million in 1995 dollars, updated annually for inflation

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They're often cited in healthspan discussions because large RCTs show benefits on major agerelated diseases including cardiovascular disease, kidney disease, obesity related heart failure and type 2 diabetes, Parkinson's disease progression, and dementia/cognitive impairment

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