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Patients with renal disease who undergo hemodialysis are at risk for secondary carnitine deficiency because hemodialysis removes carnitine from the blood (see End-stage renal disease) (38)

Currently enrolled in phase 2 clinical trials, MariTide is expected to conclude by late 2024, with future studies in phase 3 focusing on obesity and its associated conditions, including heart, liver, and kidney diseases

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The preclinical reports do not resolve that balance for systemic dosing, and no human data address it