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Due to findings of thyroid C-cell tumours in rodent studies, patients with a personal or family history of medullary thyroid carcinoma (MTC) or those with multiple endocrine neoplasia syndrome type 2 (MEN 2) should be carefully evaluated regarding the benefit-risk balance of using semaglutide

But a hard or painful lump may be a hematoma, which is a collection of blood under the skin

Some formulations tolerate brief exposure below 30C (86F), but compounded versions often require continuous refrigeration

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In the above studies, patients only experienced sustained weight loss by pairing these medications with dietary and exercise changes