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doi: 10.3389/fpls.2023.1288773 Received 04 September 2023 Accepted 06 November 2023 Published 23 November 2023 Volume 14 - 2023 Edited by Nicola Tomasi, University of Udine, Italy Reviewed by Michela Schiavon, University of Turin, Italy

In a model of sepsis-induced neuroinflammation, hydrogen has been shown to decrease the polarization of M1-type microglia while increasing the polarization of M2-type microglia through the modulation of mTOR-autophagy-dependent pathways (Zhuang et al., 2020)

Furthermore, this review explores the potential similarities and differences among these pathogens and discusses therapeutic strategies for addressing pathogen-related diseases through ferroptosis-dependent mechanisms

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