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Dihexa's primary mechanism is activation of the HGF/c-Met signaling pathway (hepatocyte growth factor / its receptor c-Met)

Oxidative stress-induced PKC can catalyze the serine and threonine residues on Ser40 in Neh2, dissociating the Keap1 homodimer, and transporting Nrf2 into the nucleus to recognize and bind the ARE/EpRE response element (Figure 1) ( in vitro studies have shown that regardless of the phosphorylation status of Nrf2, the affinity of Nrf2-sMaf heterodimers to ARE is similar ( Development of Nrf2 Inducers For exploring the preventive and alleviating efforts of Nrf2 in mouse disease models, the whole world is striving to isolate or develop effective and potentially specific Nrf2 inducing chemicals from natural sources

Under HG conditions, the mitochondrial respiratory chain releases excess ROS to the cytoplasm to signal hypoxia, triggering mitochondrial depolarization damage

After washing with 50% EtOH, the sections were coverslipped