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Pharmaceutical development shifted focus to setmelanotide, a selective MC4R agonist, which received FDA approval in 2020 specifically for genetic obesity syndromes with POMC or leptin receptor deficiency

This natural response is one of the reasons plateaus often occur during long-term GLP-1 treatment

However, a 2022 study by Stanford suggested that Metformin may be linked to sperm development that could cause birth defects in males born to fathers who were taking Metformin during conception

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Because we have determined that the cost of reporting on these measures outweighs the benefits of retaining them in these programs, it would place an undue burden on hospitals and ASCs to require reporting on these measures as we explore alternative approaches to implementing measures related to well-being and nutrition