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Ideally, WHC grades III and IV should be treated in the intensive care unit, particularly due to the potential need for orotracheal intubation to protect the airway during neurocognitive decline.29,30 9 Routine ammonia determination is not indicated for diagnosing HE or at HE follow-up

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In contrast, gut-derived GLP-1 primarily acts on GLP-1 receptors expressed on vagal sensory nerve terminals located near the intestines

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Constipation In the management of constipation, osmotic laxatives, particularly polyethylene glycol (macrogel, up to 1380 mg daily), are the most effective firstline option [3]