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Patients were randomized 1:1 to receive subcutaneous semaglutide 2.4 mg once weekly or placebo as an adjunct to standard-of-care therapy for CVD, such as cholesterol-modifying medications, antiplatelet therapies and antihypertensive agents

If GLP-1 medications are effective enough to reduce calorie consumption to recommended levels (2-2,500 calories per day) for the 5.1 million patients with weekly GLP-1 prescriptions, that would result in the cumulative reduction of approximately 2.3 trillion calories (about 0.6%) per year in the US

Methylation is a natural process that occurs in all living cells and is essential for normal growth, development, and overall health

This is why retatrutide produces higher GI rates than its dual-agonist predecessor tirzepatide