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A ketogenic diet seems to influence epigenetic changes involved in increased mitochondrial function and biogenesis (369), which might also be responsible for the increase of BDNF (370)

Stephanie Weiss, M.D., Ph.D., assistant director for the Clinical Research, Medication Development Program at NIDA, shared data from the first published clinical trial of GLP-1 RAs in alcohol use disorder: in patients with obesity with a BMI over 30, exenatide reduced heavy drinking days by 23.6% and lowered total alcohol intake

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Heat, light, or contamination exposure can cause the medication to degrade more quickly, reducing its effectiveness