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Description

Simultaneously, augmentation of nuclear MOTS-c inhibited mTORC1 activity, determined by reduced phosphorylation of 4EBP-1, P70S6K1 and mTOR (2448) (Fig

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182,183 Furthermore, inhibited ceramide synthesis or stimulation of ceramide degradation 176 can prevent the effects of ceramide on Akt/PKB activation and improve insulin signaling

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