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[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Nomura-Takigawa Y, Nagano-Fujii M, Deng L, Kitazawa S, Ishido S, Sada K, Hotta H

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Introduction: Two Dominant Anabolic Research Pathways Skeletal muscle hypertrophy research is anchored around two primary mechanistic axes: the IGF-1/IGF-1R-PI3K-Akt-mTORC1 signalling cascade driving protein synthesis, and the myostatin-ActRIIB-SMAD2/3 pathway governing muscle mass ceiling (the brake on hypertrophic growth)

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