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Post hoc mediation analysis across SURPASS-1 through SURPASS-5 found that decreases in systolic blood pressure (ranging from 1.3 mmHg to 11.5 mmHg across the tirzepatide doses) were primarily mediated through weight loss [91]

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Decreased blood sugar release: Ozempic reduces the amount of sugar released by the liver, which helps prevent blood sugar spikes

The GLP-1 Kitchen: A Cookbook for Living Well on Weight Loss Medications

Additionally, liraglutide inhibited carbon tetrachloride-induced hepatic lipid accumulation, promoted hepatocyte proliferation and suppressed apoptosis in the liver, enhancing mitochondrial respiratory function and ultimately providing liver protection effects (121,122)