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AMPK binds directly to FXR and represses the receptor via direct phosphorylation, resulting in reduced FXR transcriptional activity and, subsequently, reduced bile acid absorption [65]
On the flip side, healthcare professionals need to monitor for potential side effects such as gastrointestinal disturbances, which are common with GLP-1 receptor agonists, and the risk of pancreatitis
Weight loss itself may eventually require a dose adjustment, but that is determined by TSH monitoring, not by starting semaglutide