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MacAllister SL, Young C, Guzdek A et al (2013) Molecular cytotoxic mechanisms of chlorpromazine in isolated rat hepatocytes

Initially approved by the FDA for the treatment of type 2 diabetes, they have since also transformed the therapeutic landscape of obesity and weight management

Understanding this mechanism helps explain why some degree of urinary change might be pharmacologically driven, even if clinical trials did not flag it as a common side effect

However, the ChristianaCare review found those precautions were largely based on caution rather than strong clinical evidence

But fat shifts during weight loss are dependent on the person and not necessarily linked to sex, says Tan