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The tumor became resistant to the treatment which may be a result of target antigen heterogeneity i.e

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Blurred Vision Secondary To Eye Disease In patients whose vision is blurry secondary to eye disease, such as cataracts, glaucoma, or retinal disease, treatment of the condition may improve, stabilize, or prevent worsening of the vision

NAD Preservation: Supports higher intracellular NAD availability, promoting mitochondrial function and cellular energy production