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In both the fed and fasting groups, dosing was followed by 4-h post-dose fasting after which a standardised post-dose meal (2335 kJ, 49 E% carbohydrate, 34 E% fat and 17 E% protein) was served

not approved by the FDA, EMA or other agencies

Mounjarotirzepatide manufactured by Eli Lillywas approved by the FDA in 2022 for type 2 diabetes management, and subsequent studies showed powerful weight loss effects in people without diabetes

To address this limitation, research has concentrated on many strategies, including identifying and developing DPP-IV inhibitors 43,44 , altering the structural makeup of GLP-1, searching for structural analogues that are more resistant to DPP-IV cleavage 45 , and increasing its hydrodynamic radius ( R h) above the glomerular filtration cutoff by conjugating it to proteins such as transferrin 46 , albumin 47 , and elastin-like polypeptides 48

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