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As they head to Phase III, Zealand and Roche are betting a cleaner patient experience can offset weaker weight loss than rival amylin agonists Although Zealands petrelintide has fallen short of other clinical amylin programs on efficacy, its benign tolerability profile highlights the promise of the target in obesity

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Overdose is relatively common, and hospitalisation is usually required

Few compounds in nature demonstrate such comprehensive biological activity while maintaining an excellent safety profile

In the cardiovascular system, atherosclerosis becomes apparent as the invisible killer. Atherosclerosis causes cerebral ischemia, or angina pectoris, with the development of atherosclerotic plaques