In a comprehensive US administrative database from 2005 to 2008, GLP-1-based treatments, particularly sitagliptin and exenatide, were associated with a significantly increased risk of acute pancreatitis-related hospitalization in adults with T2DM [59], thereby reinforcing prior mechanistic experimental studies and spontaneous reports to the FDA suggesting a potential causal relationship
5-8,10 Ultimately, obesity and T2D are associated with detrimental structural changes in bone, such as decreased trabecular bone connectivity and cortical bone thickness, increasing the risk of fractures and impairing healing
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As evidence mounts and patient interest grows, integrating these therapies into everyday practice becomes not just beneficial, but essential
Patients should only use licensed GLP-1 medications prescribed by their healthcare professional