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Collectively, these trajectory analyses revealed that Lserine fundamentally reprogrammed the metabolic state of IL7R low naive CD4 T cells, and CD4 T cells were moving from a developmental bottleneck toward a functionally competent state, with potential implications for overall immune balance in patients with ASD

Results: Effect size for desire: 0.49 to 0.61 Effect size for distress reduction: 0.60 to 0.62 25% of treated patients versus 17% placebo achieved clinically meaningful desire increase 35% versus 31% achieved clinically meaningful distress reduction A 52-week open-label extension confirmed sustained efficacy and safety (PMC6819021, PMC6819023)