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Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)

doi: 10.1016/j.phrs.2019.104462 70

Contributions of the brain angiotensin IV-AT4Receptor subtype system to spatial learning

T Cells Nanoparticles encapsulating siRNA targeting c-Rel effectively suppress T helper 1 (Th1)/17 (Th17) cytokines [interferon gamma (IFN-), IL-17], halting disease progression in CIA models

Am J Human Gen (1997) 61:A98