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Citation: Maras B, Angiolella L, Mignogna G, Vavala E, Macone A, Colone M, et al

The mutation in ALDH4A1 leads to the accumulation of pyrroline-5-carboxylate (P5C) in the mitochondria, which can react with PLP to cause PLP deficiency in the brain and can also be converted to proline, resulting in elevated plasma proline levels (Fig

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[77] The precise function of vitamin K was not discovered until 1974, when prothrombin, a blood coagulation protein, was confirmed to be vitamin K dependent

Prescribing GLP-1 agonists for AUD would constitute off-label use , which requires careful consideration of the evidence base, documented informed consent, clear rationale, appropriate monitoring, and adherence to local governance frameworks