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In fact, its thought that as many as 90% of the people who follow these diets are deficient in vitamin B-12 because one of the only natural sources for B-12 is in animal food products

2 Notice of Concern J Pharmacol Exp Ther (PubMed)2021 editorial Notice of Concern over image integrity in the 2013 McCoy et al

A decline in precursors and salvage pathway efficiency: Your body recycles NAD+ using compounds like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)

The most defensible reading is to treat each compounds own within-trial data as its evidence and to treat any cross-compound ranking as a hypothesis, not a result

[13] [14] Some historical or research protocols have used much higher doses (e.g., 250 mg/kg as a single IV bolus in diagnostic growth-hormone testing), but such regimens are uncommon outside controlled studies