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In yet a further embodiment, the sterilization occurs through an autoclave

Some researchers prefer this option during the initial low-dose escalation phase, then switch to a higher concentration for maintenance dosing

Some protocols move toward 0.5 mg per day under close medical supervision if a provider determines a higher dose is appropriate for a specific patient

This is generally related to the caloric deficit rather than the medication itself, and it typically resolves as caloric intake stabilizes