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AOD-9604 AOD-9604 is primarily recognized for its potential to stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (the transformation of non-fatty foods into body fat)

OA Table 2 shows that while they were able to get statistical significance for their primary endpoint (which was a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke,) they did not achieve statistical significance for any of their confirmatory or supportive secondary endpoints, including the individual endpoints from the composite

The outer layer of the skin, Stratum Corneum, is around 1020 m (very thin), but it is the main barrier for drug penetration

However, trial participants consistently lost weight while taking them, which prompted further research into their use for weight management

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