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The big difference is supposed to be that chemical agents absorb UV-light while physical agents reflect it like a bunch of mini umbrellas on top of the skin

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This distinction is what makes them theoretically better suited for long-term autoimmune management than broad immunosuppressants

Another novel inflammatory cytokine is IL-33 which exerts its effects by binding to the orphan receptor suppression of tumorigenicity 2 (ST2), leading to the activation of various signaling pathways resulting in neuronal death (Sun et al