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In the STEP 1 to STEP 4 studies, 1% to 2% of semaglutide patients reduced their dose of lipid-lowering medication versus 0 to 1% with placebo, and 1% to 4% of patients in the semaglutide group had a dose increase versus 2% to 5% of placebo patients

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For example, proinflammatory cytokines such as IL-1 have been shown to impair neurotransmitter homeostasis (e.g., decreased serotonin levels and enhanced glutamatergic excitotoxicity), induce oxidative stress (OS) and neuronal pyroptosis, and lead to mitochondrial dysfunction and synaptic protein lossultimately fostering a bidirectional relationship between epilepsy and depression (Zhu et al., 2006