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Factors that may trigger perioral dermatitis include the following: Drugs: steroid creams, ointments, and inhalers Fluorinated toothpaste Skincare lotions and creams, especially those containing petroleum jelly, paraffin base, and isopropyl myristate Sunscreens Makeup products Certain scented skincare products Ultraviolet (UV) light Heat Dust Wind Certain infections Oral contraceptives Hormones Vitamin B12 deficiency What are the signs of perioral dermatitis

Bellanti et al., 2022

Clinicians have reported that lipedema progresses through 3 stages (Table 1), characterized by an increasing accumulation of adipose tissue, and can manifest in 5 different types, classified by where the adipose tissue accumulates (Table 2)

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Cytochrome P450 3A, ontogeny and drug disposition