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But very high doses may not be more beneficial

Prevention of neutrophil extravasation by hepatocyte growth factor leads to attenuations of tubular apoptosis and renal dysfunction in mouse ischemic kidneys

86 Some evidence suggests individuals with MTHFR polymorphisms may need higher doses of folic acid to experience therapeutic benefits and may respond better to supplementation with 5-methyltetrahydrofolate (5-MTHF), the active form of this B vitamin

Washington, DC: National Academies Press (US) (2001)

This clinically studied combination supports bone density, cardiovascular health, and immune function working together the way nature intended, not in isolation