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As a result, it will promote independence

[15] Anti-estrogens are clinically used in the treatment of breast cancer and to reduce the breast cancer incidence in high-risk women

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Comparative structural analyses suggested that transition between the open and closed conformations in DHDPRs is determined by the binding of both substrate and nucleotide, given that only the DPA/NADPH-bound form of Pa DHDPR showed a closed conformation