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Depletion of glutathione by buthionine sulfoximine is cytotoxic for human neuroblastoma cell lines via apoptosis
Copper (Cu) is essential for the activation of superoxide dismutase (SOD, antioxidant defense), lysyl oxidase (collagen cross-linking), and wound-healing enzymes
It upregulates key glycolytic enzymes (HK2, PKM2) and vascular endothelial growth factor (VEGF), promoting vascular remodeling and alveolar space enlargement, while inhibiting the proliferation and repair of alveolar epithelial cells ( 4.3 Small airway disease Small airway disease, however, serves as the primary pathological driver of airflow limitation in COPD
Raun et al., 1998 European Journal of Endocrinology Researchers tested different peptides to see how strongly (and selectively) they stimulated GH release