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This process involves the participation of two distinct isoforms of transferrin receptors, namely, transferrin receptor 1 (TFR1) and transferrin receptor 2 (TFR2) (Gomme et al., 2005)

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It is initiated through two principal pathways: the extrinsic (death receptor-mediated) and intrinsic (mitochondrial) pathways, which converge on the activation of executioner caspases (Fig

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