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This review searched literature published between 2005 and 2021 using keywords cytokines, chemokines, protein targets, small molecular metabolites, and epigenetics, and summarizes recent advances in these novel targets

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However, selenium should not be routinely supplemented in non-deficient individuals [55, 63], in particular because chronic excess may lead to toxicity (selenosis)

The most common adverse events were nausea, constipation and vomiting