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For the LEfSe analysis, an alpha of 0.05 was set for the KruskalWallis tests among classes, and per-sample normalization was performed to bring the sum of the values to 1 M

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Our integrative analysis identifies the dysregulation of plasma tryptophan and phenylalanine, coupled with a consistent alteration in the gut bacterial genus Bacteroides , as core components of this network

Some studies suggest that Epitalon may support normal pineal gland function, helping regulate circadian rhythm and improve sleep quality

Note: Results vary from person to person based on genetics, current skin tone, and lifestyle habits