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What data currently exists on the impact of GLP-1s on menstrual cycles, ovulation, fertility, or menopause symptoms

The FDA adverse event database has flagged 182 cases of GLP-1-associated sexual dysfunction since 2003, which is a weak signal, not a clear causal link

The standard dosing schedule starts at 2.5 mg weekly and escalates every four weeks: Weeks 14: 2.5 mg weekly (initiation dose to acclimate to GLP-1/GIP receptor activation) Weeks 58: 5 mg weekly Weeks 912: 7.5 mg weekly (optional intermediate step) Weeks 1316: 10 mg weekly Weeks 1720: 12.5 mg weekly (optional intermediate step) Week 21 onward: 15 mg weekly (maximum maintenance dose) Tirzepatide is injected subcutaneously just under the skin using a pre-filled pen or syringe

[DOI] [PMC free article] [PubMed] [Google Scholar] Foyer CH, Souriau N, Perret S, Lelandais M, Kunert KJ, Pruvost C, Jouanin L

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