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The triple-hormone mechanism (GLP-1, GIP, and glucagon) means it has a stronger effect on your appetite and digestive system than single or dual-hormone treatments like Wegovy or Mounjaro

Note: Some GLP-1s are not approved for weight loss, but some doctors may prescribe them off-label for this use

Retatrutide Fatigue: Causes, Management Tips, and When to Seek Help Key Takeaways Fatigue is a typical adverse effect of retatrutide because of metabolic adjustments, decreased calorie consumption, and hormonal changes that influence your vitality

Many people who take these medications, whether they are microdosing at home or taking under a doctors care, are primarily concerned about weight loss

(2023, April 19)