Ko, MD Key Facts Clinical Issues Majority develop in adolescence Microscopic Pathology Flat surface to slightly raised to polypoid Epidermis varies (e.g., thin or seborrheic keratosis-like) Well-circumscribed Melanocytes arranged in regular clusters/nests, particularly at junction of epidermis and dermis and superficial dermis Nest defined as 3-5 clustered melanocytes Generally symmetrical from side to side Orderly arrangement of nests at junction and in superficial dermis Mitoses generally absent Melanin pigment often limited to junctional or superficial dermal nests Dermal maturation: Type A nevus cells superficially, type B and C nevus cells with descent into dermis Type A nevus cells: Epithelioid Type B nevus cells: Lymphocytoid Type C nevus cells: Spindled, neuroid May see pseudonuclear inclusion: Lighter staining round area within nucleus Top Differential Diagnoses Atypical/dysplastic/Clark nevus Congenital melanocytic nevus DDx of junctional lentiginous melanocytic nevus Lentigo (simple) DDx of intradermal nevus (especially neurotized) Neurofibroma TERMINOLOGY Synonyms Benign melanocytic nevus, junctional melanocytic nevus, compound melanocytic nevus, intradermal melanocytic nevus, common mole, common melanocytic nevus, nevocellular nevus ETIOLOGY/PATHOGENESIS Exact Etiology Unknown Believed by some to arise from intraepidermal melanocytes Others suggest that melanocytic nevi arise from nerves or pluripotential cells Tumor vs
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While findings remain promising, additional research is needed to better understand their mechanisms and broader scientific applications
A GLP-1 weight loss plateau is a period when weight loss slows or temporarily stops during treatment, even though the medication may still be helping with appetite, food noise, portion control, and metabolic health
8 However, its underlying pathogenic mechanisms remain incompletely understood
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