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No causal relationship has been established in humans to date, and population-level data from large GLP-1 user cohorts have not shown a clear increase in MTC incidence.[5] That said, there are defined contraindications: GLP-1 therapy is not appropriate for patients with a personal or family history of MTC or Multiple Endocrine Neoplasia type 2 (MEN2 syndrome)

Parsons LH, Hurd YL

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10.1080/14740338.2025.2465870 Exp Opin Drug Safety 15

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