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Semaglutidea GLP-1 receptor agonist originally developed for type 2 diabetesdemonstrates comparable efficacy in male populations, with trials showing average weight reductions of 10-15% over 68 weeks when combined with lifestyle modification

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Small human studies and observational analyses have also suggested reductions in substance cravings, relapse rates, and alcohol-related hospitalizations among some patients receiving GLP-1 therapies