GLP-1 is an acronym for glucagon-like peptide-1, which is a hormone synthesized within the gastrointestinal tract
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It may have also stimulated oxidative utilization of glucose instead of converting pyruvate into lactate and contributed to decrease lactate production with metformin poisoning
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Genome-wide association studies (GWAS) in humans show that the GIPR locus contributes to body weight (BW) regulation and GIPR knockout mice are protected from diet-induced obesity (DIO) 27,28,29,30,31,32