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Overall, MSCs do not possess antigen presentation ability and rely on inducing factors to influence the expression of cytokines, suppress T cells, reduce B cell activation and proliferation, or inhibit NK cell proliferation and cytotoxicity while promoting anti-inflammatory immune cells including Tregs, Bregs, CD1c + dendritic cells (DCs) and M2 macrophages (Fig

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In fact, as outlined above, HF is even more prevalent amongst people with obesity than amongst those with type 2 diabetes, and the consequences of excess body weight (i.e., adipose tissue) most likely play direct and indirect key roles in the development of HF