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The scientists commented that the results of in vitro measurements using pQCT and Archimedes principle, in addition to ash weight determinations, show that the increases in cortical and total BMC were due to an increased growth of the bones with increased bone dimensions, whereas the volumetric BMD was unchanged

Further investigations of inherent variations of the GIPR within the normal population reveal that the missense GIPR variant, rs1800437 (Glu354Gln) that results in diminished GIPR signalling, leads to lower BMD and increased risk of non-vertebral fractures in perimenopausal Danish women

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Even then, peptide drugs remained limited by delivery challenges, Kates said

NaBPC157 was given intravenously (i.v.)