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And then, uh Evan, quickly, uh I want to get you out on a question that I'm going to guess you are asked by investors, which is okay, talk about GLP-1s, this is all we talk about

Some users report needing dose adjustments to manage side effects, while others discontinue use due to discomfort

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Food and Drug Administration (FDA) in 2005 for the treatment of type 2 diabetes

In the periphery, posttranslational processing of preproglucagon in the alpha-cells of the pancreas produces glucagon and a small amount of GLP-1 whereas the main source of peripheral GLP-1 production occurs through the posttranslational processing of preproglucagon in the L-cells of the gut (reviewed in Holst, 1992