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Figure 7 2.7 Potential molecular mechanisms of drug synergies In both the double and triple drug combinations, processes generating ROS (NADH dehydrogenase, NADH quinone oxidoreductase/complex I) and antioxidant activities are significantly dysregulated ( Figures 7A, B )

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We and others showed that administration of LAC leads to a rapid regulation of plasticity of brain areas such as the hippocampus and the connected prefrontal cortex, which are implicated in MDD and are among the first brain structures to degenerate in Alzheimers Disease (AD) [26, 30, 34,35,36, 45]