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Tesofensine APPETITE SUPPRESSANT / WEIGHT LOSS SUPPORT / MOOD-STABILIZER Mechanism of Action: Tesofensine is a triple monoamine reuptake inhibitor (T-MRI) that increases levels of dopamine, norepinephrine, and serotonin in the brain

This is mechanistically demonstrated in breast cancer models, where SFN, by activating the Nrf2 pathway, reduces the secretion of prostaglandin E2 (PGE2) from tumor cells, thereby triggering MDSCs to switch from an immunosuppressive to an immunogenic phenotype and inhibiting their expansion (76)

This aniline has been detected in the plasma of patients after oral administration of the drug 5 and exposure has been associated with hepatotoxicity 2