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OR11-01 efficacy and safety of setmelanotide in acquired hypothalamic obesity: results from a double-blind, multicenter, placebo-controlled, randomized phase 3 trial

Answer: yes, and realistically one matters

Toxicol Lett 241:918

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Used together, their combined effect on inflammatory tone appears to be more comprehensive than either achieves independently, helping to limit the tissue damage and metabolic dysfunction that chronic inflammation drives over years and decades [13,14]