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Novo has since launched a broad late-stage program for CagriSema, including the Phase III trials REDEFINE 1, which is assessing its efficacy as a weight loss therapy, and REDEFINE 2, designed to include type 2 diabetes patients with excess body weight
After reconstitution, refrigerate at 28C and use within 14 days
Patients should be offered this alternative after an informed discussion on the advantages and disadvantages of both treatment options. oral vitamin B12 is an effective alternative to vitamin B12 IM injections Cochrane Review
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However, a 2006 study published in the Journal of the American Medical Association found that a 4,000 mg dose taken for four days caused elevated serum AST and ALT, which are markers of liver injury and damage
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