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In chronic liver disease, this could be expressed through significant reduction of clinical outcomes such as the development of cirrhosis and its complications (ascites, hepatic encephalopathy, gastrointestinal hemorrhage), as well as all-cause mortality 7

For type 2 diabetes, NICE has established specific criteria for NHS-funded use, including previous treatment history and glycaemic targets

(2) Combination therapy approaches: some drugs currently used for inflammation-related diseases may have limited efficacy and narrow treatment window, such as NAC, and studies have indicated the stronger therapeutic effect of co-treatment of SA and NAC than monotherapy with NAC, which provided a novel insight into the clinical treatment strategies

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Limited long-term safety data