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Beyond altering the permeability of the BBB, acrylamide disrupts multiple lipid metabolic pathways, including cholesterol, arachidonic acid, sphingolipid, and phospholipid metabolism, mainly through the dysregulation of upstream PPAR signaling, which is heavily involved in lipid metabolism (74)

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Toxicity is usually due to exceeding the recommended daily dosage, often occurring due to accidental combination use of multiple products containing acetaminophen or through changes in dosage amounts by manufacturers

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