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Thus, throughout the manuscript (as with GLP-1 glucoregulatory function above), we aim to highlight studies that directly examine endogenous gut peptide action via receptor knockdown or antagonism
In OVX rat, administration of semaglutide at ~ 21 and 43 g/kg/day resulted in body weight loss in the animals, but also to improvement in BMD at the axial and appendicular skeleton associated with a reduction in BTMs [58]
doi: 10.1007/s00125-017-4318-z
So while we arent comparing apples to apples when comparing GLP-1 stimulated via diet versus a GLP-1 from medication, we also know that not everyone can take a GLP-1 medication
Risks of GLP-1 Pharmaceutical Drugs Nausea Vomiting Abdominal pain Constipation Heartburn Flatulence Gastritis Acute kidney injury Pancreatitis Gallstones Ileus Medullary thyroid cancer risk As a result of the above adverse effects, interest has grown in natural ways to increase GLP-1 activity through foods, supplements, and lifestyle changes
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