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Metalloporphyrins contain Mn or Fe metals coordinated by four donor nitrogens in a square planar arrangement and have been reported to scavenge superoxide radicals (O 2 ) (Pasternack and Skowronek 1979), hydrogen peroxide (H 2 O 2 ), peroxynitrite (ONOO ) and hydroperoxides (LOOH) (Day et al

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conclude that CRC cells can acquire chemoresistance through the B7-H3/CDC25A axis